Sperm are "washed" and then placed in the uterus during ovulation. In most cases, IUI is done along with taking hormone medication to stimulate egg development. The medication can be oral (pills or vaginal suppositories) or injections. When a combination of oral and injectable medications are used, it is referred to as a hybrid cycle.

Insemination increases the pregnancy rate ~ 2-4 folds when combined with ovulation induction.

Indication for insemination include: 

• Male factor infertility. Many men has abnormal semen analysis. Low sperm count, decreased sperm motility or abnormal sperm shape can lead to infertility. This can often be treated with intrauterine insemination (IUI). It is estimated that 200 - 300 sperm are able to reach the egg during timed sex. Insemination allows millions of sperm to reach the egg thus increasing the chances for pregnancy. 
• Unexplained infertility 
• Endometriosis
• Polycystic ovarian syndrome
• When the couple fail ovulation induction with timed sex